Host-Pathogen Interactions
The pathogenesis of Shigella
The pathogenesis of Shigella
We use the intracellular pathogen Shigella as a model system to study bacterial behavior in the human host. Our main interest is to learn how bacteria sense their surroundings to cause disease. We are investigating:
Metabolic byproducts as signals to coordinate gene expression
The role of c-di-GMP signalling in regulating virulence
Using intestinal enteroids ('mini-guts') to study Shigella pathogenesis